Therefore, my dear brothers and sisters, stand firm. Let nothing move you. Always give yourselves fully to the work of the Lord, because you know that your labor in the Lord is not in vain. (1 Corinthians 15:58, NIV)
There is a kind of work that fails to satisfy. This is not to say that such work is not helpful, or even necessary, on some level.
However, if we are to engage in the kind of work that endures beyond our years, and that satisfies us at the core of our being; it must be work that is motivated by our desire to give glory to God. Any work — no matter how menial — that is undertaken in obedience to God; or that is rendered as a service to God is never in vain.
If your work seems pointless, ask yourself: “What is the point?” – Luther